Increased knowledge of thalassemia promotes early carrier status examination among medical students
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Abstract
Thalassemia is an autosomal recessive genetic disorder, in which the patient requires life-long blood transfusion. As Indonesia harbors 6 to 10% thalassemia carriers, thalassemia prevention measures such as early screening and education in the community are urgently needed. The aim of this study was to explore the knowledge, attitude and practice about thalassemia among young medical students.
METHODS
A cross-sectional analytic observational study was conducted on 179 subjects in 2015, using a questionnaire with items on knowledge, attitude and practice about thalassemia for data collection. After signing informed consent, the questionnaire was filled in by the students and a blood test was performed when the students agreed to be examined. Detection of probable thalassemia carrier status was done by determination of hemoglobin, mean corpuscular volume and mean corpuscular hemoglobin.
RESULTS
The knowledge about thalassemia of the first year medical students (n=179) was good (21.1%), moderate (70.9%) and poor (21.1%). Only 67 (38.3%) of the students agreed to a blood examination for determination of their carrier status after filling-in the questionnaire. The knowledge of thalassemia among first year medical students was statistically related to the timing when they would agree to have their thalassemia carrier status examined (p=0.021, one way ANOVA test).
CONCLUSION
A higher thalassemia knowledge score causes medical students to be willing to undergo thalassemia carrier status examination at an earlier point in timing. A well-organized educational program focusing on thalassemia and early screening in young adults may enhance the thalassemia prevention program.
Article Details
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References
Cao A, Kan YW. The prevention of thalassemia. Cold Spring Harb Perspect Med 2013;3:a011775. doi: 10.1101/cshperspect. a011775.
Saffi M, Howard N. Exploring the effectiveness of mandatory premarital screening and genetic counselling programmes for â-thalassaemia in the Middle East: a scoping review. Public Health Genomics 2015;18:193-203.
Verma IC, Saxena R, Kohli S. Past, present & future scenario of thalassaemic care & control in India. Indian J Med Res 2011;134:507-21.
Rahimah AN, Nisha S, Safiah B, et al. Distribution of alpha thalassaemia in 16 year old Malaysian students in Penang, Melaka and Sabah. Med J Malaysia 2012;67:565-70.
Gaziev J, Marziali M, Isgro A, et al. Bone marrow transplantation for thalassemia from alternative related donors: improved outcomes with a new approach. Blood 2013;122:2751-6.
Saliba AN, Harb AR, Taher AT. Iron chelation therapy in transfusion-dependent thalassemia patients: current strategies and future directions. J Blood Med 2015;6:197-209.
Schoorl M, Schoorl M, van Pelt J, et al. Application of innovative hemocytometric parameters and algorithms for improvement of microcytic anemia discrimination. Hematol Rep 2015;7:5843. doi: 10.4081/hr.2015.5843
Benoist B, McLean E, Egll I, et al. Worldwide prevalence of anaemia 1993–2005: WHO global database on anaemia. Geneva: World Health Organization; 2008.
Viprakasit V, Limwongse C, Sukpanichnant S, et al. Problems in determining thalassemia carrier status in a program for prevention and control of severe thalassemia syndromes: a lesson from Thailand. Clin Chem Lab Med 2013;51:1605-14.
Ip HW, So CC. Diagnosis and prevention of thalassemia. Crit Rev Clin Lab Sci 2013;50: 125-41.
Wong LP, George E, Tan JA. Public perceptions and attitudes toward thalassaemia: Influencing factors in a multi-racial population. BMC Public Health 2011;11:193. doi: 10.1186/1471-2458-11-193.
Hashemizadeh H, Noori R. Premarital screening of beta thalassemia minor in north-east of Iran. Iran J Ped Hematol Oncol 2013;3:210-5.
Widayanti CG, Ediati A, Tamam M, et al. Feasibility of preconception screening for thalassaemia in Indonesia: exploring the opinion of Javanese mothers. Ethn Health 2011; 16:483-99.
Amato A, Cappabianca MP, Lerone M, et al. Carrier screening for inherited haemoglobin disorders among secondary school students and young adults in Latium, Italy. J Community Genet 2014;5:265-8.
Miri-Moghaddam E, Motaharitabar E, Erfannia L, et al. High school knowledge and attitudes towards thalassemia in southeastern Iran. Int J Hematol Oncol Stem Cell Res 2014;8:24-30.
Giordano PC, Harteveld CL, Bakker E. Genetic epidemiology and preventive healthcare in multiethnic societies: the hemoglobinopathies. Int J Environ Res Public Health 2014;11:6136-46.
Ahmadnezhad E, Sepehrvand N, Jahani FF, et al. Evaluation and cost analysis of national health policy of thalassaemia screening in West-Azerbaijan province of Iran. Int J Prev Med 2012;3:687-92.
Wong LP, George E, Tan JA. A holistic approach to education programs in thalassemia for a multi-ethnic population: consideration of perspectives, attitudes, and perceived needs. J Community Genet 2011;2:71-9.
Ansari SH, Baig N, Shamsi TS, et al. Screening immediate family members for carrier identification and counseling: a cost-effective and practical approach. J Pak Med Assoc 2012;62: 1314-7.
Kementerian Kesehatan Republik Indonesia. Peraturan pemerintah Republik Indonesia nomor 61 tahun 2014 tentang kesehatan reproduksi. Available at: http://www.kemenpppa.go.id/jdih/peraturan/PP-Nomor-61-Tahun-2014-Tentang-KESEHATAN-REPRODUKSI.pdf. Accessed May 11, 2015.