The role of polyphenols in causing cardiovascular disease

Main Article Content

Yenny Yenny
Elly Herwana

Abstract

Research on flavonoids has increased since the discovery of the French Paradox, the low cardiovascular mortality rate observed in Mediterranean population in association with red wine consumption and a high saturated fat intake. Plant polyphenol (flavonoid) occurs naturally in fruits, vegetables, and beverages such as tea and wine. Epidemiologic studies suggest that higher polyphenol intake from fruits and vegetables is associated with decreased risk for cardiovascular disease. The mechanisms explaining this observation remain unclear. The vascular endothelium is a critical regulator of vascular homeostasis, and endothelial dysfunction contributes to the pathogenesis and clinical expression of coronary artery disease. Platelet aggregation is a central mechanism in the pathogenesis of acute coronary syndromes, including myocardial infarction and unstable angina. There are numerous reports suggesting that plant polyphenols improve endothelial function and inhibit platelet aggregation in humans.

Article Details

How to Cite
Yenny, Y., & Herwana, E. (2008). The role of polyphenols in causing cardiovascular disease. Universa Medicina, 27(1), 29–38. https://doi.org/10.18051/UnivMed.2008.v27.29-38
Section
Review Article

References

American Heart Association. Heart and stroke statistical update. Dallas: American Heart Association, 2000.

Expert Panel. Executive summary of the third report of the National Cholesterol Education Program (NCEP). Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 2001; 285: 2486-97.

Kullo IJ, Gau GT, Tajik AJ. Novel risk factors for atherosclerosis. Mayo Clin Proc 2000; 75: 369-80.

Knekt P, Kumpulainen J, Jarvinen R, Rissanen H, Reunanen A, Hakulinen T, et al. Flavonoid intake and risk of chronic disease. Am J Clin Nutr 2002; 76: 560-8.

Vita JA. Polyphenols and cardiovascular disease: effects on endothelial and platelet function. Am J Clin Nutr 2005; 8(Suppl): 292S-7S.

Vita JA, Keaney JF Jr. Endothelial function: a barometer for cardiovascular risk? Circulation 2002; 106: 640-2.

Gokce N, Vita JA. Clinical manifestations of endothelial dysfunction. In: Loscalzo J, Schafer AI, eds. Thrombosis and hemorrhage. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 685-706.

Widlansky ME, Gokce N, Keaney JF Jr, Vita JA. The clinical implications of endothelial dysfunction. J Am Coll Cardiol 2003; 42: 1149-60.

Leeson CPM, Hingorani AD, Mullen MJ. Glu298Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function. Circ Res 2002; 90: 1153-8.

Nijveldt RB, van Nood E, van Hoorn DEC, Boelens PG, van Norren K, van Leeuwen PAM. Flavonoid: a review of probable mechanism of action and potential applications. Am J Clin Nutr 2001; 74: 418-25.

Cheynier V. Polyphenol in foods are more complex than often thought. Am J Clin Nutr 2005; 81(Suppl): 223S-9S.

Bravo L. Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev 1998; 56: 317-33.

Harborne JB, Williams CA. Advances in flavonoid research since 1992. Phytochemistry 2005; 55: 481-504.

Leenen R, Roodenburg AJ, Tijburg LB, Wiseman SA. A single dose tea with or without milk increases plasma antioxidant activity in humans. Eur J Clin Nutr 2000; 54: 87-92.

Pignatelli P, Pulcinelli FM, Celestini A. The flavonoids quercetin and catechin synergistically inhibit platelet function by antagonizing the intracellular production of hydrogen peroxide. Am J Clin Nutr 2000; 72:1150-5.

Duffy SJ, Keaney JF, Holbrook M. Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. Circulation 2001; 104: 151-6.

Peter J, Poole C, Arab L. Does tea affect cardiovascular disease? A meta-analysis. Am J Epidemiol 2001; 154: 495-503.

Geleijnse JM, Launer LJ, van der Kuip DAM, Hofman A, Witterman JCM. Inverse association of tea and flavonoid intakes with incident myocardial infarction: the Rotterdam Study. Am J Clin Nutr 2002; 75: 880-6.

Arai Y, Watanabe S, Kimira M, Shimoi K, Mochizuki R, Kinae N. Dietary intakes of flavonols, flavone dan isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J Nutr 2000; 130: 2243-50.

Modena MG, Bonetti L, Coppi F, Bursi F, Rossi R. Prognostic role of reversible endothelial dysfunction in hypertensive postmenopausal women. J Am Coll Cardiol 2002; 40: 505-10.

Huang A, Vita JA, Venema RC, Keaney J. Ascorbic acid enhances endothelial nitric oxide synthetase activity by increasing intracellular tetrahydrobiopterin. J Biol Chem 2000; 275: 399-406.

Hodgson JM, Puddey IB, Burke V, Watts GF, Beilin LJ. Regular ingestion of black tea improves brachial artery vasodilator function. Clin Sci 2002; 102: 195-201.

Folts D. Potential health benefits from the flavonoids in grape products on vascular disease. Adv Exp Med Bio 2002; 505: 95-111.

Wang Z, Zou J, Cao K, Hsieh TC, Huang Y, Wu JM. Dealcoholized red wine containing known amounts of resveratrol suppresses atherosclerosis in hypercholesterolemic rabbits without affecting plasma lipid level. Int J Mol Med 2005; 16: 533-40.

Guarda E, Godoy I, Foncea R, Perez DD, Romero C, Venegas R, et al. Red wine reduces oxidative stress in patients with acute coronary syndrome. Int J Cardiol 2005; 104: 35-8.

Perez-Vizcaino F, Duerte J, Andriantsitohaina R. Endothelial function and cardiovascular disease: effects of quercetin and wine polyphenols. Free Radic Res 2006; 40: 1054-65.

Heiss C, Dejam A, Kleinbongard P, Schewe T, Sies H, Kelm M. Vascular effects of cocoa rich in flavan-3-ols. JAMA 2003; 290: 1030-1.

Wang-Polagruto JF, Villablanca AC, Polagruto JA, Lee L, Holt RR, Schrader HR, et al. Chronic consumption of flavanol-rich cocoa improves endothelial function and decreases vascular cell adhesion molecules in hypercholesterolemic postmenopausal women. J Cardiovasc Pharmacol 2006; 46: 177-86.

Awtry EH, Loscalzp J. Aspirin. Circulation 2000; 101: 1206-18.

Freedman JE, Parker III C, Li L, Perlman JA, Frei B, Ivanav V, et al. Selected flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 2001; 103: 2792-8.

Duffy SJ, Vita JA, Holbrook M, Swerdloff PL, Keaney JF Jr. Effect of acute and chronic tea consumption on platelet aggregation in patients with coronary artery disease. Arterioscler Thromb Vasc Biol 2001; 21: 1084-9.

Hodgson JM, Puddey JB, Mori TA, Burke V, Barker RI, Beilin LJ. Effects of regular ingestion of black tea on haemostasis and cell adhesion molecules in humans. Eur J Clin Nutr 2001; 55: 881-6.