ISSN 2407-2230 | E-ISSN 1907-3062 | Universa Medicina content is searchable on DOAJ, Google Scholar, and OAI

Multimicronutrient supplementation in older persons decreased zinc deficiency but not serum TNF-

Elly Herwana, Yenny Yenny
Submission date: Tuesday, 23 February 2016
Published date: Tuesday, 23 February 2016
DOI: http://dx.doi.org/10.18051/UnivMed.2011.v30.102-110

Abstract


The increase in the population of older persons needs to be accompanied by increased quality of healthcare in older persons, particularly a decrease in the incidence of infections. Impaired immune responses are common in older adults, and immune senescence likely contributes to the increased incidence of infectious diseases in the older persons. The aging process decreases the immune response and many studies have been conducted to explain the role of supplementation with various micronutrients, such as vitamin C, vitamin E, â-carotene and zinc, on the immune response. The aim of the present study was to assess the influence of 6 months of multi-micronutrient (MMN) supplementation on zinc and tumor necrosis factor (TNF-á) levels in older persons. A randomized controlled trial was conducted on 78 older persons, who were divided into two groups. The treatment group received MMN supplementation containing 40 mg elemental zinc, 120 mg ascorbic acid, 6 mg â-carotene, 15 mg á-tocopherol  and 400 ìg folic acid and the control group 400 mg calcium carbonate. The study did not demonstrate that 6 months of MMN supplementation resulted in significant differences between both groups, with respect to total protein, albumin, globulin, and TNF-á levels. In contrast, MMN supplementation significantly decreased the proportion of older persons with zinc deficiency in the treatment group, in comparison with the control group. The present data suggest that in older persons with relatively good immune and protein status, improvement of the immune status by MMN supplementation may be difficult and at best limited.

Keywords


Multimicronutrients; TNF-a; protein; zinc; older persons

Full Text:

PDF

References


Mobbs C. The Merck manual of geriatrics, Section 2, Chapter 2, Biology of Aging. Available at: http://www.merck.com/pubs/mm_geriatrics/sec2/ch 2.html. Accessed July 23, 2007.

Badan Pengembangan Pembangunan Nasional, Badan Pusat Statistik, United Nations Population Fund. Proyeksi penduduk Indonesia 2000-2025. Jakarta: Pengembangan Pembangunan Nasional, Badan Pusat Statistik, United Nations Population Fund;2005.

Hoffman C, Rice D, Sung HY. Persons with chronic conditions: their prevalence and costs. JAMA 1996;276:1473-9.

Yenny, Herwana E. The prevalence of chronic disease and quality of life in elderly people. Univ Med 2006;25:164-71.

Field CJ, Johnson IR, Schley PD. Nutrients and their role in host resistance to infection. J Leukoc Biol 2002;71:16-32.

Berkow RL, Wang D, Larrick JW, Dodson RW, Howard TH. Enhancement of neutrophil superoxide production by preincubation with recombinant human tumor necrosis factor. J Immunol 1987;139:3789-91.

Maggini S, Wintergerst ES, Beveridge S, Hornig DH. Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses. Br J Nutr 2007;98 Suppl 1:S29-35.

Prasad AS, Beck FWJ, Bao B, Fitzgerald JT, Snell DC, Steinberg JD, et al. Zinc supplementation decreases incidence of infection in the elderly: effect of zinc on generation of cytokines and oxidative stress. Am J Clin Nutr 2007;85:837-44.

Prasad AS, Bao B, Beck FWJ, Kucuk O, Sarkar FH. Antioxidant effect of zinc in humans. Free Radic Biol Med 2004;37:1182–90.

Yalcin SS, Engur-Karasimav D, Alehan D, Yurdakok K, Ozkutlu S, Coskun T. Zinc supplementation and TNF-á levels in vaccinated cardiac patients. J Trace Elem Med Biol 2011; doi:10.1016/j.jtemb.2011.03.002.

Lesourd B. Nutritional factors and immunological ageing. Proc Nutr Soc 2006;65:319-25.

World Health Organization. Appropriate body mass index for Asian populations and its implications for policy and intervention strategies. Lancet 2004;363:157-63.

Maret W, Sandstead HH. Zinc requirements and the risks and benefits of zinc supplementation. J Trace Elem Med Biol 2006;20:3–18.

Albers R, Antoine JM, Bourdet-Sicard R, Calder PC, Gleeson M, Lesourd B, et al. Markers to measure immunomodulation in human nutrition intervention studies. Br J Nutr 2005;94:452–81.

Prasad AS. Effects of zinc deficiency on immune functions. J Trace Elem Exp Med 2000;13:1-20.

Meydani SN, Barnett JB, Dallal GF, Fine BC, Jacques PF, Leka LS, et al. Serum zinc and pneumonia in nursing home elderly. Am J Clin Nutr 2007;86:1167–73.

Wells JL, Dumbrel AC. Nutrition and aging: assessment and treatment of compromised nutritional status in frail elderly patients. Clin Interv Aging 2006;1:67-79.

Mucci E, Jackson SHD. Nutritional supplementation in community-dwelling elderly people. Ann Nutr Metab 2008;52 Suppl 1:S33-7.

Russell RM. Factors in aging that effect the bioavailability of nutrients. J Nutr 2001;131Suppl 4:S1359-61.

Shenkin A. Micronutrients in health and disease. Postgrad Med J 2006;82:559-67.

Fabian E, Elmadfa I. Nutritional situation of elderly in the European Union: data of the European nutrition and health report. Ann Nutr Metab 2008;52 Suppl 1:S57-61.

Tucker KL, Buranapin S. Nutrition and aging in developing countries. J Nutr 2001;131: S2417-23.

Haase H, Rink L. The immune system and the impact of zinc during aging. Immunity Ageing 2009;6:9-26.

Tam M, Gomez S, Gonzalez-Gross M, Marcos A. Possible roles of magnesium on the immune system. Eur J Clin Nutr 2003;57:1193-7.

Hamer DH, Semportegui F, Estrella B, Tucker KL. Micronutrient deficiencies are associated with impaired immune response and higher burden of respiratory infections in elderly Equadorians. J Nutr 2009;139:113-20.

Marti L, Cervera C, Filella X, Marin JL, Almela M, Moreno A. Cytokine release patterns in elderly patients with systemic inflammatory response syndrome. Gerontol 2007;53:239-44.


Refbacks

  • There are currently no refbacks.


Copyright (c) 2016 Universa Medicina



Creative Commons License
Universa Medicina by Faculty of Medicine, Trisakti University is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Based on a work at https://univmed.org/ejurnal/index.php/medicina/